Relationship of neurovascular compression to central sympathetic discharge and essential hypertension

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Relationship of neurovascular compression to central sympathetic discharge and essential hypertension.

OBJECTIVES We planned to examine the relationship between neurovascular compression (NVC) of the rostral ventrolateral medulla (RVLM) and the magnitude of central sympathetic hyperactivity in normal subjects and in patients with untreated and uncomplicated essential hypertension (EHT). BACKGROUND Previously it has not been possible to establish a definitive relationship between EHT and NVC of...

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Neurovascular compression: sympathetic activity in severe arterial hypertension.

Compression of the rostral ventrolateral medulla oblongata (RVLM) by an abnormally located artery is regarded as one possible cause of arterial hypertension. There exists a limited set of data suggesting that increased sympathetic activity in patients with RVLM compression may lead to arterial hypertension. Accordingly, we decided to assess the sympathetic activity in patients with severe arter...

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Hypertension in patients with neurovascular compression is associated with increased central sympathetic outflow.

Recent data suggest a causal relationship between essential hypertension and neurovascular compression (NVC) at the rostral ventrolateral medulla. An increase of central sympathetic outflow might be an underlying pathomechanism. The sympathetic nerve activity to muscle was recorded in 21 patients with hypertension with NVC (NVC+ group) and in 12 patients with hypertension without NVC (NVC- grou...

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In the present study, we established dose-response relationships between central administration of 4-hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl (Tempol, a superoxide dismutase mimetic) and the level of renal sympathetic nerve discharge (SND) and tested the hypothesis that intracerebroventricular (icv) Tempol pretreatment would attenuate centrally mediated changes in SND produced by icv ANG II...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2004

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2003.11.047